|
|||||
|
|
Expression of Activin Receptor-like Kinase 7 in Adipose Tissues |
|
| Authors: | Masaru Murakami Mitsuyuki Shirai Ryo Ooishi Asako Tsuburaya Kumiko Asai Osamu Hashimoto Kenji Ogawa Yoshii Nishino Masayuki Funaba |
| Institution: | 1. Laboratory of Molecular Biology, School of Veterinary Medicine, Azabu University, Sagamihara, 252-5201, Japan 2. Laboratory of Veterinary Pharmacology, School of Veterinary Medicine, Azabu University, Sagamihara, 252-5201, Japan 3. Laboratory of Experimental Animal Science, School of Veterinary Medicine, Kitasato University, Towada, 034-8628, Japan 4. Chemical Genomics Research Group, ASI, Riken, Wako, 351-0198, Japan 5. Department of Animal Medical Sciences, Faculty of Life Sciences, Kyoto Sangyo University, Kyoto, 603-8555, Japan 6. Division of Applied Biosciences, Kyoto University Graduate School of Agriculture, Kyoto, 606-8502, Japan |
| Abstract: | The tissue distribution of activin receptor-like kinase 7 (Alk7) expression, the signaling ability of Alk7 variants, and Alk7 expression in response to β3-adrenergic receptor activation were examined. Expression levels of Alk7 varied greatly among tissues but were highest in white adipose tissue and brown adipose tissue. In addition to full-length Alk7 (Alk7-v1), Alk7-v3, an Alk7 variant, was expressed in adipose tissues, brain, and ovary. Nodal transmits signals via Alk7 in cooperation with its coreceptor, Cripto. Evaluation of the ability of Alk7 variants to confer Nodal signaling using luciferase-based reporter assays showed that Alk7-v3 does not transmit Nodal-Cripto-mediated signals. Expression of Alk7 was down-regulated in brown but not in white adipose tissue treated with CL316,243, a β3-adrenergic receptor agonist. These results suggest involvement of Alk7 in modulation of metabolism in the adipose tissues in response to β3-adrenergic receptor activation. |
| Keywords: | |
| 本文献已被 SpringerLink 等数据库收录！ | |