Detailed analysis of the CD8+ T-cell response following adenovirus vaccination |
| |
Authors: | Yang Teng Chih Dayball Kelley Wan Yong Hong Bramson Jonathan |
| |
Institution: | Center for Gene Therapeutics, Department of Pathology and Molecular Medicine, McMaster University, Hamilton, Ontario L8N 3Z5, Canada. |
| |
Abstract: | We examined CD8(+) T-cell expansion and function following intramuscular immunization with a recombinant adenovirus. This study has identified a number of properties which may explain the strong immunogenicity of adenovirus vectors: (i) the ability to deliver large amounts of antigen into the lymphoid tissues, (ii) the ability to induce rapid expansion and migration of CD8(+) T cells throughout the lymphatics, and (iii) the ability to produce a sustained, high-level CD8(+) T-cell response. |
| |
Keywords: | |
本文献已被 PubMed 等数据库收录! |
|