Functional characterization of Pneumocystis carinii brl1 by transspecies complementation analysis |
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| Authors: | Lo Presti Libera Cockell Moira Cerutti Lorenzo Simanis Viesturs Hauser Philippe M |
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| Institution: | Institute of Microbiology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, 1011 Lausanne, Switzerland. |
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| Abstract: | Pneumocystis jirovecii is a fungus which causes severe opportunistic infections in immunocompromised humans. The brl1 gene of P. carinii infecting rats was identified and characterized by using bioinformatics in conjunction with functional complementation in Saccharomyces cerevisiae and Schizosaccharomyces pombe. The ectopic expression of this gene rescues null alleles of essential nuclear membrane proteins of the Brr6/Brl1 family in both yeasts. |
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