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Metabolic alteration in tumorigenesis |
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| Authors: | Hui Yang Yue Xiong KunLiang Guan |
| Institution: | 1. Molecular and Cell Biology Lab, Institutes of Biomedical Sciences, Shanghai Medical College; School of Life Sciences, Fudan University, Shanghai, 200032, China 2. Department of Biochemistry and Biophysics and Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, 27599, USA 3. Department of Pharmacology and Moores Cancer Center, University of California San Diego, La Jolla, CA, 92093, USA |
| Abstract: | Altered metabolism in cancer was first discovered by Otto Warburg early last century. Although the Warburg Effect has been widely used in tumor detection, relatively little progress had been made in mechanistic understanding of cancer metabolism in the subsequent eight decades. Genetic studies have recently identified mutations in human cancer targeting multiple enzymes involved in intermediate metabolism. One emerging mechanism common to these mutant enzymes is the accumulation of a metabolite that alters the epigenetic control. |
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