Role of p53 family in birth defects: lessons from zebrafish |
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Authors: | Danilova Nadia Sakamoto Kathleen M Lin Shuo |
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Institution: | Department of Molecular, Cell and Developmental Biology, University of California, Los Angeles, California 90095-1606, USA. ndanilova@ucla.edu |
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Abstract: | p53 Protein family is an important teratologic suppressor, but in certain conditions it can cause congenital abnormalities. p53 Family performs this dual role in development by integrating information from cell's interior with that from the environment to determine the choice between life and death. Understanding of p53 family developmental functions may lead to new therapeutic approaches for treatment and prevention of birth defects. Zebrafish is becoming the vertebrate system of choice for studying p53 family role in development. |
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Keywords: | zebrafish p53 p63 p73 congenital abnormalities |
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