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Rapid Diagnostic Tests for Dengue Virus Infection in Febrile Cambodian Children: Diagnostic Accuracy and Incorporation into Diagnostic Algorithms
Authors:Michael J. Carter  Kate R. Emary  Catherine E. Moore  Christopher M. Parry  Soeng Sona  Hor Putchhat  Sin Reaksmey  Ngoun Chanpheaktra  Nicole Stoesser  Andrew D. M. Dobson  Nicholas P. J. Day  Varun Kumar  Stuart D. Blacksell
Abstract:BackgroundDengue virus (DENV) infection is prevalent across tropical regions and may cause severe disease. Early diagnosis may improve supportive care. We prospectively assessed the Standard Diagnostics (Korea) BIOLINE Dengue Duo DENV rapid diagnostic test (RDT) to NS1 antigen and anti-DENV IgM (NS1 and IgM) in children in Cambodia, with the aim of improving the diagnosis of DENV infection.ConclusionsThe DENV RDT had low sensitivity for the diagnosis of DENV infection. The high co-prevalence of infections in our cohort indicates the need for a broad microbiological assessment of non-localised febrile illness in these children.
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