Bcl-2-regulated cell death signalling in the prevention of autoimmunity |
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Authors: | D Tischner C Woess E Ottina A Villunger |
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Affiliation: | 1Division of Developmental Immunology, BIOCENTER, Medical University Innsbruck, Innsbruck, Austria |
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Abstract: | Cell death mediated through the intrinsic, Bcl-2-regulated mitochondrial apoptosis signalling pathway is critical for lymphocyte development and the establishment of central and maintenance of peripheral tolerance. Defects in Bcl-2-regulated cell death signalling have been reported to cause or correlate with autoimmunity in mice and men. This review focuses on the role of Bcl-2 family proteins implicated in the development of autoimmune disorders and their potential as targets for therapeutic intervention. |
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Keywords: | apoptosis Bcl-2 family BH3-only proteins autoimmunity |
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