Comparison of the inhibitory effects of mexiletine and lidocaine on the calcium current of single ventricular cells |
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| Authors: | K Ono T Kiyosue M Arita |
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| Affiliation: | 1. Department of Human and Artificial Intelligence Systems, Faculty of Engineering, University of Fukui, Fukui 910-8507, Japan;2. Department of Materials Science and Biotechnology, Faculty of Engineering, University of Fukui, Fukui 910-8507, Japan;3. Life Science Innovation Center, University of Fukui, Fukui 910-8507, Japan;1. Department of Cardiac, Thoracic and Vascular Sciences and Public Health, University of Padova, Padova, Italy;2. Department of Neuroscience, University of Padova, Padova, Italy;3. Department of Biomedicine and Prevention, Medical Genetics Section, University of Rome "Tor Vergata", Rome, Italy;1. University of Padova, Department of Biomedical Sciences, Via Ugo Bassi 58/B, 35131, Padova, Italy;2. Venetian Institute of Molecular Medicine, Via G. Orus, 2, 35129, Padova, Italy;3. CNR Institute of Neurosciences, Viale Colombo 3, 35133, Padova, Italy;1. Leviev Heart Center, Sheba Medical Center, Tel Hashomer and Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel;2. Cardiac Research Lab, Felsenstein Medical Research Center, Sackler School of Medicine, Tel Aviv University, Tel Aviv, Israel;3. Faculty of Life Sciences, Bar Ilan University, Ramat Gan, Israel |
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| Abstract: | Effects of mexiletine and lidocaine on inward calcium current (ICa) of single ventricular myocytes from guinea pigs were studied using tight seal whole cell clamp method. Mexiletine at the concentrations of 10, 30 and 100 microM decreased ICa by 23.0, 28.9 and 55.4%, respectively, while lidocaine decreased it by 8.9, 16.8 and 25.2%. At all concentrations tested, a potency for ICa inhibition in mexiletine was significantly greater than that in lidocaine (p less than 0.05). The results suggest that mexiletine has, at therapeutic concentrations, a considerable blocking action on the Ca channels other than well-known action on the Na channels. |
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