嗜肺军团菌核酸疫苗研究进展

嗜肺军团菌通过气溶胶的形式感染人和动物,引起军团菌性肺炎,危害极其严重,但该病目前尚无有效的预防措施。军团菌病疫苗的研究经历了灭活疫苗、减毒活疫苗和蛋白亚单位疫苗不同阶段,但至今尚未能在临床得到应用。核酸疫苗作为一种新型疫苗,能有效诱导机体产生细胞免疫应答,符合兼胞内寄生菌嗜肺军团菌的预防需要,并且还具有诸多其他优点,引起了研究者们的兴趣。对嗜肺军团杆菌核酸疫苗的研究现状进行了简要介绍。

Progress on developing DNA vaccine against Legionella pneumophila

Legionnaires ’ disease is generally infected by inhalation of aerosol containing Legionella pneumophila from con-taminated environmental source , which has a great damage to human health , but there is no effective measure to prevent it . The development was carried out on inactivated vaccine , attenuated live vaccine and subunit peptide vaccine , but up to now all of these have not been clinically applied .DNA vaccine , a new kind of vaccine , can induce cell-mediated immunity to meet human demand of preventing intracellular bacterium Legionella pneumophila.DNA vaccine has a number of advanta-ges, thus researchers were very intrested in this aspect .This article reviewed the progress on developing DNA vaccine in prevention of Legionnaires ’ disease.