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Synthesis and urease enzyme inhibitory effects of some dicoumarols |
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| Authors: | Khan Khalid M Iqbal Sajid Lodhi Muhammad A Maharvi Ghulam M Perveen Shahnaz Choudhary M I Atta-Ur-Rahman Chohan Zahid H Supuran Claudiu T |
| Institution: | H.E.J. Research Institute of Chemistry, International Center for Chemical Sciences, University of Karachi, Karachi, Pakistan. hassaan2@super.net.pk |
| Abstract: | Dicoumarols 1-10 with substituted phenyl residues at C-11 were synthesized and screened for their urease inhibition effects. All synthesized compounds showed varying degree of urease inhibitory activity ranging from IC50 = 74.30-91.35 microM. |
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