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Immunomodulation of carcinogens-induced steroids-dependent human diseases |
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| Authors: | Andrew N Glushkov Elena G Polenok |
| Institution: | Institute of Human Ecology, Federal Research Center of Coal and Coal Chemistry of Siberian Branch of the Russian Academy of Sciences, Kemerovo 650065, Russian Federation |
| Abstract: | The experimental and clinical data about antibodies against environmental chemical carcinogens and endogenous steroids are represented. The conception of immunomodulation of carcinogens- and steroids-dependent human diseases is proposed. It is postulated that antibodies to polycyclic aromatic hydrocarbons and heterocyclic amines in cooperation with antibodies to cholesterol, sex hormones, mineralo- and glucocorticoids stimulate or inhibit cancer, malformation, cardiovascular and autoimmune diseases depending on their personal combination. It is recommended to use immunoassay of these antibodies for the human diseases prediction. The alternative approaches for prevention using the probiotics transformed by anti-carcinogen antibodies are substantiated. |
| Keywords: | Cg chemical carcinogens PAH polycyclic aromatic hydrocarbons S steroids PE phytoestrogens Bp benzo[a]pyrene ER estrogen receptors Abs antibodies Es estradiol Pg progesterone PR progesterone receptors LC lung cancer BC breast cancer LCP lung cancer patients BCP breast cancer patients MW women with malformation HW healthy women ER+ estrogen receptors positive ER? estrogen receptors negative PR+ progesterone receptors positive PR? progesterone receptors negative cAhR cytoplasmic mAhR membrane aril hydrocarbon receptors cytochrome P-450 Antibody formation Benzo[a]pyrene Cholesterol Estradiol Progesterone Prediction Prevention |
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