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| 不同RF型类风湿性关节炎患者Th17相关细胞因子表达研究 | |
| 引用本文： | 厉吉霞,姜虹 由红雷 王斌 钱冬萌. 不同RF型类风湿性关节炎患者Th17相关细胞因子表达研究[J]. 现代生物医学进展, 2011, 11(4): 729-731 |
| 作者姓名： | 厉吉霞 姜虹 由红雷 王斌 钱冬萌 |
| 作者单位： | 1. 青岛大学医学院病原微生物教研室,山东,青岛,266021;烟台市烟台山医院,山东,烟台,264001 2. 烟台市烟台山医院,山东,烟台,264001 3. 青岛大学医学院病原微生物教研室,山东,青岛,266021 |
| 摘 要： | 目的:探讨类风湿因子阳性与阴性类风湿关节炎(rheumatoid arthritis,RA)患者外周血中辅助T细胞(Th17)及相关细胞因子白介素17(interleukin,IL-17),白介素6(interleukin,IL-6)表达的差异。方法:收集RA患者51例,根据RF测定分为RF+、RF-组,健康查体者(对照组)20例,采用流式细胞术检测受检者外周血单个核细胞(PBMC)的Th17细胞的百分率;以酶联免疫吸附法(ELISA)检测受检者血浆中IL-17,IL-6的水平。结果:RA患者CD4+IL-17+T细胞,IL-17、IL-6水平均高于对照组,RF因子阳性与阴性RA患者之间CD4+IL-17+T细胞,IL-17、IL-6表达水平均存在差异有统计学意义。结论:在RA中不同RF型免疫反应和炎症表达的不同,可能与Th17及相关细胞因子表达差异有关。 |
| 关 键 词： | 类风湿性关节炎 类风湿因子 Th17 IL-17 IL-6 |
Expression of Th17 Type Cytokines in Rheumatoid ArthritisPatients with RF+ and RFLI |
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| LIJi-xi,JIANG Hong,YOU Hong-lei,WANG Bin,QIAN Dong-meng. Expression of Th17 Type Cytokines in Rheumatoid ArthritisPatients with RF+ and RFLI[J]. Progress in Modern Biomedicine, 2011, 11(4): 729-731 | |
| Authors: | LIJi-xi JIANG Hong YOU Hong-lei WANG Bin QIAN Dong-meng |
| Affiliation: | LI Ji-xia1,2,JIANG Hong2,YOU Hong-lei2,WANG Bin1,QIAN Dong-meng1(1 Department of pathogenic microorganism Qingdao University Medical College,266021,Qingdao China,2 Yantaishan hospital,264001,Yantai China) |
| Abstract: | Objective:To investigate the different expression of Th17 type cytokines in the peripheral blood of rheumatoid arthri-tis patients with rheumatoid factor positive(RF+) and rheumatoid factor negative(RF-).Methods:51 RA patients including RF+ and RF-and 20 healthy subjects were studied.The percentage of Th17 cell in single PBMC was determined by flow cytometry and the levels of IL-17 and IL-6 in plasma were detected by Enzyme-linked immunosorbent assay(ELISA) in all subjects.Results:Th17 cell and the con-cent... |
| Keywords: | Rheumatoid arthritis Rheumatoid factor Th17 cell IL-17 IL-6 |
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