| 表观遗传学研究进展 |
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| 引用本文： | 李光雷,喻树迅,范术丽,宋美珍,庞朝友.表观遗传学研究进展[J].生物技术通报,2011(1). |
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| 作者姓名： | 李光雷 喻树迅 范术丽 宋美珍 庞朝友 |
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| 作者单位： | 中国农业科学院棉花研究所,安阳,455000 |
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| 基金项目： | 国家高技术研究发展计划项目(“863”计划)(2009AA101104) |
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| 摘 要： | 表观遗传学是在基因组DNA序列不发生变化的条件下,基因表达发生的改变也是可以遗传的,导致可遗传的表现型变化。表观遗传学主要包括DNA甲基化作用、组蛋白修饰作用、染色质重塑、遗传印记、随机染色体(X)失活及RNA世界等。与表观遗传学相关的疾病主要有肿瘤、心血管病、精神病和自身免疫系统性病等。现就表观遗传学与疾病进行综述。
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| 关 键 词： | 表观遗传学 疾病 DNA甲基化 组蛋白修饰 癌症 |
Advances of Research on Epigenetics |
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| Li Guanglei,Yu Shuxun,Fan Shuli,Song Meizhen,Pang Chaoyou.Advances of Research on Epigenetics[J].Biotechnology Bulletin,2011(1). |
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| Authors: | Li Guanglei Yu Shuxun Fan Shuli Song Meizhen Pang Chaoyou |
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| Institution: | Li Guanglei Yu Shuxun Fan Shuli Song Meizhen Pang Chaoyou(Cotton Research Institute,Chinese Academy of Agricultural Sciences,Anyang 455000) |
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| Abstract: | Epigenetics refers to phenotypic changes caused by mechanisms that are unrelated to changes in the underlying DNA sequence,changes in gene expression also can occur genetically,resulting in heritable changes in phenotype.Epigenetics includes DNA methylation,histone modification,chromatin remodeling,imprinting,random chromosome(X)inactivation,RNA world,etc.Epigenetics-related diseases mainly includes cancer,cardiovascular disease,mental illness,human autoimmune diseases.This paper is an overview of epigeneti... |
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| Keywords: | Epigenetics Diseases DNA methylation Histone modification Cancer |
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