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VIP in cerebrospinal fluid of patients with multiple sclerosis |
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| Authors: | O Andersen J Fahrenkrug C Wikkelsø BB Johansson |
| Institution: | 1. Department of Neurology, Sahlgren Hospital, S-413 45 Göteborg, Sweden;2. Department of Clinical Chemistry, Bispebjerg Hospital, 2400 Copenhagen, Denmark;3. Department of Neurology, University Hospital, S-221 85 Lund, Sweden |
| Abstract: | The concentration of VIP was measured radioimmunochemically in cerebrospinal fluid (CSF) from 14 healthy volunteers and from 22 patients with multiple sclerosis. Significantly lower levels of VIP was obtained in the patients (18 +/- 3 pmol/l) than in controls (37 +/- 4 pmol/l). There was no correlation between the level of VIP in CSF and other CSF parameters such as albumin. IgG or cell content; nor between VIP concentration and the physical handicap or neuropsychiatric symptoms. There was a trend towards lower values of VIP in patients with steadily progressing rather than intermittent course of the disease but the difference between the groups was not significant. |
| Keywords: | Cerebrospinal fluid (CSF) VIP Healthy volunteers Multiple sclerosis |
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