Fusion proteins between PML and alpha-RAR in acute promyelocytic leukemia] |
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| Authors: | P Kastner A Perez Y Lutz C Rochette-Egly M P Gaub P Chambon |
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| Affiliation: | Laboratoire de Génétique Moléculaire des Eucaryotes du CNRS, U/184 de Biologie Moléculaire et de Génie Génétique de l'INSERM, Faculté de Médecine, Strasbourg, France. |
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| Abstract: | Acute promyelotic leukemia is characterized by a t(15;17) chromosomal translocation which results in fusion products between PML (chromosome 15) and RAR-alpha (chromosome 17). We describe 2 classes of patients which possess different PMLRAR and RARPML fusion transcripts. We then discuss the functional properties of PML and show that PMLRAR can interfere with both PML and RAR-alpha functions. |
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