Fungal biotransformation of p-coumaric acid into caffeic acid by Pycnoporus cinnabarinus: an alternative for producing a strong natural antioxidant |
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| Authors: | Estrada Alvarado Isabel Navarro David Record Eric Asther Michèle Asther Marcel Lesage-Meessen Laurence |
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| Institution: | (1) Unité Mixte de Biotechnologie des Champignons Filamenteux de l'INRA, IFR de Biotechnologie Agro-Industrielle de Marseille, ESIL, Universités de Provence et de la Méditerranée, CP 925, 163 avenue de Luminy, 13288 Marseille cedex 09, France |
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| Abstract: | Fungal biotransformation of p-coumaric acid into caffeic acid, potentially a strong antioxidant, was evidenced in Pycnoporus cinnabarinus cultures grown with high feeding of p-coumaric acid. Preliminary experiments showed no toxicity of both p-coumaric and caffeic acids at concentrations ranging from 0 to 500 mg l–1. Feeding 450 mg p-coumaric acid l–1 into P. cinnabarinus cultures grown on 20 g l–1 glucose medium resulted in the production of 257 mg caffeic acid l–1with a molar yield of 21%. |
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| Keywords: | Antioxidant biotransformation caffeic acid p-coumaric acid Pycnoporus cinnabarinus |
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