2型糖尿病周围血管病的危险因素分析

目的:探讨2型糖尿病周围血管病发病的风险因素。方法:随机选取342例2型糖尿病患者,其中279例2型糖尿病合并周围血管病,63例未合并周围血管病,对比分析两组的性别、年龄、BMI指数、病程、有无吸烟史、有无高血压病史、尿酸、胱抑素C、总胆红素、直接胆红素、间接胆红素、前白蛋白等。依据双下肢动脉狭窄程度将279例合并周围血管病患者分为4组:狭窄率50%(组1)、狭窄率50%至75%(组2)、狭窄率75%(组3)、下肢闭塞(组4),分析和比较不同狭窄程度组间上述各项基础资料及指标间差异,危险因素采用多元Logistic回归分析。结果:下肢动脉狭窄程度与胱抑素C为正相关关系(r=0.227,P0.05);下肢动脉狭窄程度与前白蛋白为负相关关系(r=-0.181,P0.05)。结论:胱抑素C为2型糖尿病周围血管病的危险因素,前白蛋白为2型糖尿病周围血管病的保护因素,临床可将二者用于糖尿病周围血管病患者的诊治监测指标。

A Study on the Risk Factors of Peripheral Vascular Disease of Type 2 Diabetes

ABSTRACT Objective: To investigate the effects of cystatin C, uric acid, total bilirubin, direct bilirubin, indirect bilirubin, and prealbumin on the risk of peripheral vascular disease in type 2 diabetes. Methods: Randomly selected 342 patients with type 2 diabetes, including 279 patients with type 2 diabetes and peripheral vascular disease, and 63 patients without peripheral vascular disease. The gender, age, BMI index, course of disease, history of smoking, No history of hypertension, uric acid, cystatin C, total bilirubin, direct bilirubin, indirect bilirubin, prealbumin, etc. In addition, 279 patients with peripheral vascular disease were divided into 4 according to the degree of arterial stenosis of both lower limbs Group: stenosis rate <50 % (group 1), stenosis rate 50 % to 75 % (group 2), stenosis rate> 75 % (group 3), lower extremity occlusion (group 4), analysis of the above items between groups with different degrees of stenosis Differences between basic data and indicators. SPSS 25.0 software was used for data analysis. Comparison between groups was performed using independent sample t-test or analysis of variance. Post hoc comparisons were performed using LSD test. Comparisons between groups were performed using x2 test. The correlation between the two samples was analyzed using Kendall''s tau-b correlation analysis. The risk factors were analyzed by multiple logistic regression. Results: The degree of arterial stenosis of the lower limbs was positively correlated with cystatin C (r=0.227, P<0.05); the degree of arterial stenosis of the lower limbs was negatively correlated with prealbumin (r=-0.181, P<0.05). Conclusion: Cystatin C is a risk factor for peripheral vascular disease in type 2 diabetes, and prealbumin is a protective factor for peripheral vascular disease in type 2 diabetes.