食道癌组织miR-21、miR-182表达与临床病理特征及预后的关系

目的:探讨食道癌组织微小RNA-21(miR-21)、微小RNA-182(miR-182)表达与临床病理特征及预后的关系。方法:选取2011年4月到2013年7月期间在我院接受手术治疗的食道癌患者84例,取患者的癌组织和癌旁正常组织作为检验标本,比较癌组织和癌旁正常组织中miR-21、mi R-182的表达水平,并分析食道癌组织中mi R-182、mi R-21的表达与临床病理特征及预后的关系。结果:癌组织中mi R-21、mi R-182的相对表达量明显高于癌旁正常组织,差异有统计学意义(P<0.05)。食道癌组织中mi R-21的表达与淋巴结转移、临床分期有关(P<0.05),与性别、年龄、分化程度、肿瘤大小无关(P>0.05);食道癌患者癌组织中miR-182的表达与年龄、性别、肿瘤大小无关(P>0.05),与分化程度、临床分期、淋巴结转移有关(P<0.05)。食道癌癌组织中miR-21、miR-182高表达患者的中位生存时间均低于低表达患者,差异有统计学意义(P<0.05)。结论:食道癌组织mi R-21、mi R-182表达与患者的部分临床病理特征及预后有关,两者有望成为食道癌新的治疗靶点。

Relationship between Expression of miR-21 and miR-182 in Esophageal Cancer and Clinicopathological Features and Prognosis

ABSTRACT Objective: To investigate the relationship between the expression of miR-21 and miR-182 in esophageal cancer and clinicopathological features and prognosis. Methods: 84 patients with esophageal cancer who underwent surgery in our hospital from April 2011 to July 2013 were enrolled. The cancer tissues and paracancerous normal tissue were taken as test specimens. The expression levels of miR-21 and miR-182 in cancer tissues and paracancerous normal tissues were compared. The relationship between the expression of miR-21 and miR-182 in esophageal cancer and clinicopathological features and prognosis were analyzed. Results: The relative expression levels of miR-21 and miR-182 in cancer tissues were significantly higher than those in paracancerous normal tissues (P<0.05). The expression of miR-21 in esophageal cancer patients was not correlated with age, gender, tumor size and differentiation degree (P>0.05), and it was correlated with clinical stage and lymph node metastasis(P<0.05). The expression of miR-182 in esophageal cancer tissues was not correlated with age, sex and tumor size(P>0.05), and it was correlated with differentiation degree, clinical stage and lymph node metastasis (P<0.05). The median survival time of patients with high expression of miR-21 and miR-182 in esophageal cancer tissues was lower than that in patients with low expression(P<0.05). Conclusion: The expression of miR-21 and miR-182 in esophageal cancer tissues is related to some clinicopathological features and prognosis of patients, and it is expected to become a new therapeutic target for esophageal cancer.