不同预防性抗生素用于肿瘤患者围手术期的成本-效果分析

目的:探究不同抗生素用于肿瘤患者围手术期的成本-效果。方法:选择于我院接受手术治疗的93例肺癌患者,所有患者按照随机数字表法均分为三组,每组31例,三组患者实施不同的抗生素预防方案,对比三组患者的一般手术情况(手术时间、术中出血量、术后7 d最高体温、术后住院时间)、抗生素应用效果(术后呼吸道感染率、术后7 d平均体温、术后7 d平均白细胞计数)以及不同抗生素预防方案成本-效果。结果:(1)三组患者手术时间、术中出血量、术后7 d最高体温、住院时间对比差异均无统计学意义(P0.05);(2)三组患者术后呼吸道感染率、术后7 d平均体温、术后7 d平均白细胞计数对比差异均无统计学意义(P0.05);(3)A组患者具有最高的成本-效果比值,单位效果所花费的成本显著低于B、C两组(P0.05)。结论:术前预防及术后短疗程应用头孢唑林钠能够显著降低肺癌患者术后感染率,减少抗生素用量及花费,提高患者围手术期成本-效果。

Cost-effectiveness Analysis of Different Prophylactic Antibiotics in Perioperative Period of Cancer Patients

ABSTRACT Objective: To explore the cost-effectiveness of different antibiotics for the perioperative period of patients with tumor. Methods: 93 patients with lung cancer who underwent surgery in our hospital were selected. All patients were divided into three groups according to the random number table method, with 31 cases in each group. Three groups of patients implemented different antibiotic prophylaxis programs. The general surgery conditions of the three groups were compared (surgery time, intraoperative blood loss, postoperative operation). 7 days maximum body temperature, postoperative hospital stay), antibiotic application effect (postoperative respiratory infection rate, average body temperature at 7 days after surgery, average white blood cell count at 7 days after surgery) and cost-effectiveness of different antibiotic prevention programs. Results: (1) There was no significant difference in the operation time, intraoperative blood loss, maximum body temperature and hospitalization time between the three groups (P>0.05). (2) There were no significant differences in postoperative respiratory infection rate, mean body temperature at 7 days after surgery, and mean white blood cell count at 7 days after operation (P>0.05). (3) Patients in the group A had the highest cost-effectiveness ratio, and the cost per unit effect was significantly lower than those in the groups B and C (P<0.05). Conclusion: Preoperative prevention and short-term postoperative treatment with cefazolin sodium can significantly reduce postoperative infection rate, reduce antibiotic dosage and cost, and improve perioperative cost-effectiveness.