阿司匹林联合神经节苷脂治疗脑梗塞的临床疗效观察

目的:探讨阿司匹林联合神经节苷脂治疗脑梗塞的临床疗效及可能机制。方法:选择我院2015年5月到2018年3月接诊的90例脑梗塞患者,依照抽签法将其分为实验组和对照组,每组45例。两组患者均给予常规支持治疗,对照组在此基础上给予阿司匹林治疗,实验组在对照组的基础上给予单唾液酸四己糖神经节苷脂(Monosialyl tetrahexose ganglioside, GM1)治疗。据患者美国国立卫生研究院卒中量表(National Institutes of Health Stroke Scale, NIHSS)和Barthel指数评分的改善情况,比较两组的疗效,以及治疗前后血清过氧化脂质(lipid peroxide, LPO)、超氧化物歧化酶(superoxide dismutase, SOD)、丙二醛(malondialdehyde, MDA)、一氧化氮(nitric oxide, NO)水平的变化。结果:治疗后,实验组有效率为96.86%,显著高于对照组(78.13%,P<0.05)。两组治疗后血清SOD水平及Barthel指数均较治疗前显著上升,而血清LPO、MDA、NO水平及NIHSS评分均较治疗前显著下降,实验组血清SOD水平及Barthel指数显著高于对照组,血清LPO、MDA、NO水平及NIHSS评分均明显低于对照组(P<0.05)。结论:阿司匹林联合GM1能提高脑梗塞的疗效,可能与有效提高血清SOD水平及降低LPO、MDA、NO水平有关。

Curative Efficacy of Aspirin Combined with Ganglioside in the Treatment of Cerebral Infarction

ABSTRACT Objective: To investigate the curative efficacy and possible mechanisms of aspirin combined with ganglioside in the treatment of cerebral infarction. Methods: 90 cases of cerebral infarction patients received in our hospital from May 2015 to March 2018 were selected, they were divided into the experimental group and the control group according to the lottery method, with 45 cases in each group. They were given routine supportive treatment, the control group was given aspirin treatment, and the experimental group was given monosialyl tetrahexose ganglioside (GM1) sodium injectionbased on the basis of control group. According to the improvement of National Institutes of Health Stroke Scale(NIHSS) and Barthel index scores, the efficacy and changes of serum lipid peroxide (LPO), superoxide dismutase (SOD), malondialdehyde (MDA) and nitric oxide (NO) levels before and after treatment were compared two groups. Results: After treatment, the effective rate of experimental group was 96.86%, which was significantly higher than that of the control group (78.13%, P<0.05). After treatment, the serum SOD level and Barthel index were significantly increased than those before treatment, while the serum LPO, MDA, NO levels and NIHSS score in both groups were significantly decreased than those before treatment, and the serum SOD level and Barthel index in the experimental group were significantly higher than that of the control group, the serum LPO, MDA, NO levels and NIHSS scores in the experimental group were significantly lower than that of the control group(P<0.05). Conclusion: Aspirin combined with GM1 can improve the curative effect of cerebral infarction, which may be related to the effective increase of serum SOD level and the decrease of LPO, MDA and NO levels.