吲哚箐绿联合亚甲蓝在子宫内膜癌术中前哨淋巴结识别中的应用价值

目的:探究吲哚箐绿联合亚甲蓝在子宫内膜癌术中前哨淋巴结识别中的应用价值。方法:选取2016年8月~2017年9月我院收治的子宫内膜癌患者93例,采用随机数字表法分为两组。对照组将亚甲蓝蓝染的淋巴结作为前哨淋巴结,观察组在对照组的基础上使用吲哚箐绿,蓝染和荧光显影的淋巴结作为前哨淋巴结。比较两组患者的前哨淋巴结切除时间、术中出血量、淋巴结切除数量、主动脉旁淋巴结切除例数、前哨淋巴结识别成功率,并比较两种方法的准确率、敏感性和特异性。术后随访12个月,对两组患者的复发情况和相关并发症进行比较。结果:两组患者的前哨淋巴结切除时间、术中出血量、淋巴结切除数量和主动脉旁淋巴结切除例数比较均无统计学差异(P>0.05);观察组的前哨淋巴结识别成功率、准确率和特异性均显著高于对照组(P<0.05),两组敏感度、复发率比较均无统计学差异(P>0.05)。两组在随访期间均未发生皮肤坏死、过敏或永久性着色等相关不良反应。结论:吲哚箐绿联合亚甲蓝在子宫内膜癌术中识别前哨淋巴结的应用价值显著高于单用亚甲蓝。

Application Value of Indorquine Green Combined with Methylene Blue for the Sentinel Lymph Node Identification in the Endometrial Carcinoma

ABSTRACT Objective: To explore the application value of indorquine green combined with methylene blue in sentinel lymph node identification for endometrial carcinoma. Methods: 93 cases of endometrial cancer patients admitted in our hospital from August 2016 to September 2017 were selected and divided into two groups by the random number table method. The methylene blue was used in the control group, indorquine green and methylene blue were used in the observation group. The sentinel lymph node excision time, intraoperative blood loss, number of lymph node excision, number of cases of para-aortic lymph node resection, sentinel lymph node identification rate were compared between two groups. And the accuracy, sensitivity and specificity of the two methods were also compared. All the patients were followed-up for 12 months, the relapse and incidence of related complications were compared between two groups. Results: There was no statistically significant difference in the sentinel node resection time, intraoperative blood loss, number of lymph node resection and number of para-aortic lymph node resection cases between the two groups (P>0.05). The success rate of sentinel node recognition, accuracy and specificity of the observation group was significantly higher than that of the control group (P<0.05), and there was no statistical difference in the sensitivity and recurrence rate between the two groups(P>0.05). No adverse reactions such as skin necrosis, allergy or permanent staining occurred in either group during the follow-up period. Conclusion: The application value of indoturnip-green combined with methylene blue in the identification of sentinel lymph nodes in endometrial cancer is significantly higher than that of methylene blue alone.