前哨淋巴结活检术对老年乳腺癌患者肿瘤标志物水平和生活质量的影响

目的:探讨前哨淋巴结活检术对老年乳腺癌患者肿瘤标志物水平和生活质量的影响。方法:选取2015年8月至2017年12月大连大学附属中山医院收治的80例拟行乳腺癌手术治疗的老年患者,依据手术方法分为观察组与对照组,对照组患者给予乳腺癌改良根治术治疗,观察组患者给予前哨淋巴结活检手术联合保乳术治疗,每组各40例。比较两组患者治疗前后血清癌胚抗原(CEA)、糖类抗原-153 (CA153)、糖类抗原-125(CA125)水平和生活质量评分的变化,术中情况,治疗后美学满意度及不良反应的发生情况。结果:两组患者治疗后血清CEA、CA153与CA125水平较治疗前均明显降低(均P0.05);且观察组患者以上指标均显著低于对照组(均P0.05)。观察组术中平均出血量、手术时间、总引流量及引流管拔除时间均明显短于对照组(均P0.05),生理状况、社会家庭状况、情感状况、功能状况、附加关注及生活质量总分、美学满意度均明显高于对照组(均P0.05),不良反应发生率低于对照组(均P0.05)。结论:前哨淋巴结活检辅助乳腺癌手术可提高美学满意度及生活质量,安全性更高,更有利于患者术后恢复。

Effect of Sentinel Lymph Node biopsy on the Tumor Markers and Quality of Life in the Elderly Patients with Breast Cancer

ABSTRACT Objective: To investigate the effect of sentinel lymph node biopsy on the tumor markers and quality of life in elderly patients with breast cancer. Methods: Eighty patients who underwent breast cancer surgery from August 2015 to December 2017 were enrolled in the hospital. They were divided into the observation group and the control group according to the surgical method. The control group were treated by modified radical mastectomy for treatment. Patients in the group were given sentinel lymph node biopsy combined with breast conserving surgery, 40 cases in each group. The changes of serum carcinoembryonic antigen (CEA), carbohydrate antigen-153 (CA153), carbohydrate antigen-125 (CA125) tumor marker level and quality of life score before and after treatment were compared between the two groups, and the intraoperative and post-operative quality of life scores, aesthetic satisfaction, and incidence of adverse reactions were compared. Results: There was no significant difference in the CEA, CA153 and CA125 levels between the two groups before treatment (P>0.05). The levels of serum CEA, CA153 and CA125 in the two groups were significantly lower than those before treatment(P<0.05). which were significantly lower in the observation group than those in the control group(P<0.05). The mean bleeding volume, operation time, total drainage volume and drainage tube removal time in the observation group were significantly shorter than those in the control group (all P<0.05). The physiological status, social family status, emotional status, functional status, additional attention and total quality of life, and aesthetic satisfaction in the observation group were significantly higher than the control group (all P<0.05). The aesthetic satisfaction of the observation group was significantly higher than that of the control group, and the incidence of adverse reactions was lower than that of the control group (all P<0.05). Conclusion: Sentinel lymph node biopsy assisted breast cancer surgery can promote the recovery with higher safety, it can improve the quality of life.