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Specificity and function of monoclonal antibodies directed against Ewing sarcoma cells |
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| Authors: | Liang Ru Shi Dirk Eichelbauer Franz Borchard Herbert Jürgens Ulrich Göbel E. Marion Schneider |
| Affiliation: | (1) Pathology Institute, University of Düsseldorf, Düsseldorf, Germany;(2) Department of Pediatric Oncology, University of Münster, Albert Schweitzer Str. 33, D-48149 Münster, Germany;(3) Department of Pediatrics Hematology and Oncology, University of Düsseldorf, Düsseldorf, Germany;(4) Immunology Laboratory, Institute of Blood Coagulation and Transfusion Medicine, University of Düsseldorf, P.O. Box 101007, D-40001 Düsseldorf, Germany |
| Abstract: | A selection of 16 monoclonal antibodies has been produced against a fresh Ewing's sarcoma (ES) tumor mixed with a permanent ES cell line. The majority of antibodies identify an 80-kDa molecule, which is not detected on healthy tissues except on certain cultured monocytes. One antibody recognize the CD2 ligand MIC2 and 2 antibodies (numbers 13 and 16) define a higher-molecular-mass antigen. Antibody 16 is also expressed on mesenchymal fibroblasts of bone marrow or fetal origin. Tumorspecific antigen expression is potentially linked to the chromosome 22 abnormality decribed in Ewing's sarcoma. |
| Keywords: | Ewing's sarcoma Tumor-specific monoclonal antibodies MIC-2 |
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