Identification of a novel antiangiogenic agent; 4-(N-imidazol-2-ylmethyl)amino benzopyran analogues |
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| Authors: | Kim Nakjeong Lee Sunkyung Yi Kyu Yang Yoo Sung-eun Kim Guncheol Lee Chong Ock Park Sung Hee Lee Byung Ho |
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| Affiliation: | Department of Chemistry, Chungnam National University, Taejon 305-764, South Korea. |
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| Abstract: | 
A series of 4-(N-imidazol-2-ylmethyl)aminobenzopyran analogues, originally designed as K(ATP) openers for ischemic diseases, showed antiangiogenic properties through the inhibition of HUVEC tube formation. Especially one of p-Cl substituted analogues (4c) completely inhibited HUVEC tube formation at 10 microM. The compound 4c significantly inhibited tumor growth by 52% on A549 (human non small cell lung carcinoma) in nude mice xenografts without any significant side effects. |
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