Release of pituitary melanocyte-stimulating hormone by the oxytocin fragment, H-Cys-Tyr-Ile-Gln-Asn-Oh |
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| Authors: | M E Celis S Taleisnik R Walter |
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| Institution: | 1 Instituto de Investigacion Medica, Mercedes y Martin Ferreyra, Cordoba, Argentina;2 The Department of Physiology, The Mount Sinai Medical and Graduate Schools of the City University of New York, New York, New York 10029 U.S.A. |
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| Abstract: | The effect of the pentapeptide H-Cys-Tyr-Ile-Gln-Asn-OH to act like melanocyte-stimulating hormone-releasing factor (MSH-RF) was studied. This peptide decreases at ng amounts the MSH content of the rat pituitary and increases plasma MSH concentration. This agent also stimulates the release of MSH in animals with eminence lesion, indicating a direct action of the pentapeptide on the gland. |
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