肺泡灌洗对肺脓肿患者肺表面活性蛋白A与高迁移率蛋白1水平的影响分析

目的:探讨肺泡灌洗对肺脓肿患者肺表面活性蛋白A(SPA)与高迁移率蛋白1(HMGA1)水平的影响。方法:采用回顾性、随机抽样方法,选取2014年2月-2017年6月我院诊治的120例肺脓肿患者,根据治疗方法分成观察组、对照组,每组各60例,对照组给予常规治疗,观察组在对照组的基础上进行肺泡灌洗治疗,疗程4周。比较两组的临床有效率、治疗前后肺功能、血清SPA和HMGA1水平的变化。结果:治疗后,观察组总有效率(98.3%)显著高于对照组(88.3%)(P0.05);两组的FEV1、PaO_2均较治疗前显著升高(P0.05),且观察组以上指标均显著高于对照组(P0.05);两组患者血清SPA、HMGA1水平均较治疗前显著降低(P0.05),且观察组以上指标均显著低于对照组(P0.05)。结论:肺泡灌洗可有效提高肺脓肿的临床治疗效果,显著改善患者肺功能和血气状态,可能与降低患者血清SPA与HMGA1水平有关。

Effects of Bronchoalveolar Lavage on the Surface Active Protein A and High Mobility Protein 1 Levels of Patients with Qulmonary Abscess

ABSTRACT Objective: To investigate the effects of bronchoalveolar lavage on the surface active protein A(SPA) and high mobility protein 1(HMGA1) of patients with pulmonary abscess. Methods: A retrospective, random sampling method was performed in 120 cases of patients with pulmonary abscess in our hospital from February 2014 to June 2017, they were divided into the observation group and the control group by different treatment methods with 60 patients in each group. The control group was given routine treatment, the ob- servation group was given bronchoalveolar lavage therapy based on the treatment of control group, all patients were observed for 4 weeks. The clinical efficacy, changes in lung function, serum SPA and HMGA1 levels before and after treatment were compared between the two groups. Results: The total effective rate in the observation group (98.3%) was significantly higher than that in the control group (88.3%)(P<0.05). The FEV1 and PaO₂ after treatment in both groups were significantly increased than those before treatment (P<0.05), and the above indicators of observation group were significantly higher than those in the control group (P<0.05). The serum SPA and HMGA1 levels after treatment in both groups were significantly lower than those before treatment (P<0.05), and the above indicators of observation group were significantly lower than those in control group (P<0.05). Conclusion: Bronchoalveolar lavage can effectively en- hance the clinical therapeutic effect of pulmonary abscess, significantly improve the pulmonary function and blood gas status of patients, and its mechanism may be related to the reduction of serum SPA and HMGA1 levels of patients.