四七汤联合帕罗西汀治疗脑卒中后抑郁患者的疗效评价及对血清ox-LDL、CRP、IL-6的影响

目的:探讨四七汤联合帕罗西汀治疗脑卒中后抑郁患者的疗效及对血清氧化低密度脂蛋白(ox-LDL)、C反应蛋白(CRP)、白细胞介素-6(IL-6)的影响。方法:选择我院2014年9月～2016年9月收治的86例脑卒中后抑郁患者,按治疗方式分为对照组与实验组,每组43例。对照组予以帕罗西汀治疗,实验组在对照组基础上加用四七汤治疗,两组均持续治疗8周。比较两组的临床疗效,治疗前后中医症候积分、血清ox-LDL、CRP、IL-6、汉密顿抑郁量表(HAMD)、纳维亚神经卒中量表评分(SNSS)的变化及不良反应的发生情况。结果:治疗后,实验组治疗总有效率显著高于对照组(P0.05);两组中医症候积分、血清ox-LDL、CRP、IL-6、HAMD、SNSS评分均显著下降,且实验组以上指标均明显低于对照组,差异有统计学意义(P0.05)。两组不良反应的发生率比较差异无统计学意义(P0.05)。结论:四七汤联合帕罗西汀治疗脑卒中后抑郁患者的疗效优于单用帕罗西汀者,能够有效改善患者的临床症状,可能与其更有效降低患者血清ox-LDL、CRP、IL-6水平有关。

Efficacy of Siqi Decoction and Paroxetine in Treatment of Post-Stroke Depression and Serum ox-LDL, CRP and IL-6 Levels

ABSTRACT Objective: To investigate the efficacy of Siqi decoction and paroxetine in the treatment of patients with post-stroke de- pression and effect on the serum oxidized low density lipoprotein (ox-LDL), C-reactive protein (CRP) and interleukin-6 (IL-6) levels. Methods: 86 cases of patients with post-stroke depression in our hospital from September 2014 to September 2016 were divided into the control group and the experimental group, with 43 cases in each group. The control group was treated by paroxetine treatment, while the experimental group was treated with Siqi decoction based on the control group, both groups were treated for eight weeks. The curative ef- fect, changes of chinese medicine symptom integral, serum ox-LDL, CRP, IL-6 levels, Hamilton depression scale (HAMD) and the scan- dinavians nerve stroke scale score (SNSS) levels and incidence of adverse reactions were compared between two group. Results: After treatment, the total effective rate of experimental group was significantly higher than that of the control group(P<0.05). The Chinese tra- ditional Chinese medicine, serum ox-LDL, CRP, IL-6, HAMD, SNSS scores of both group were significantly lower than those before treatment, which were significantly lower in the experimental group than those of the control group(P<0.05). No statistically significant difference was found in the incidence of adverse reactions between the two groups(P>0.05). Conclusion: The curative effect of Siqi de- coction and paroxetine was better than that that paroxetine alone in treatment patients with poststroke depression, it can effectively im- prove the clinical symptoms, which may be related to the reduce of serum levels of ox-LDL, CRP and IL-6.