经皮椎体成形术对老年骨质疏松性胸腰椎压缩骨折患者血清MMP-3、TIMP-1、IL-6及疗效的影响

目的:探讨经皮椎体成形术对老年骨质疏松性胸腰椎压缩骨折患者血清基质金属蛋白酶-3(MMP-3)、基质金属蛋白酶抑制因子-1(TIMP-1)、白细胞介素-6(IL-6)及疗效的影响。方法:选择60例2016年10月到2017年3月我院接诊的老年骨质疏松性胸腰椎压缩骨折患者,依照随机数表法分为实验组和对照组,每组30例,在都给予常规药物治疗的基础上,对照组给予复位枕垫和康复训练治疗,实验组采用经皮椎体成形术治疗。结果:治疗前,两组血清MMP-3、TIMP-1、IL-6水平无差异(P0.05);治疗后,两组血清MMP-3、IL-6水平均降低,实验组下降幅度更大,两组血清TIMP-1水平均升高,实验组上升幅度更大(P0.05);治疗前,两组患者VAS评分无差异(P0.05),治疗1周及治疗后,实验组患者VAS评分均低于对照组(P0.05);治疗前,两组患者Cobb角无差异(P0.05),治疗后,两组患者Cobb均明显下降,实验组较对照组下降更大(P0.05);治疗前,两组患者伤椎高度比无差异(P0.05),治疗后,两组伤椎高度比明显下降,实验组低于对照组(P0.05);治疗后,实验组有效率96.67%大于对照组的76.67%,差异显著(P0.05)。结论:经皮椎体成形术能有效降低患者血清MMP-3、IL-6水平,恢复TIMP-1水平,能显著提高治疗老年骨质疏松性胸腰椎压缩骨折的疗效

Effects of Percutaneous Vertebroplasty on Serum MMP-3, TIMP-1, IL-6 and Efficacy in Elderly Patients with Osteoporotic Thoracolumbar Vertebral Compression Fracture

ABSTRACT Objective: To investigate the effects of percutaneous vertebroplasty on serum levels of matrix metalloproteinase-3 (MMP-3), matrix metalloproteinase-1 (TIMP-1) and interleukin- (IL-6) and therapeutic effect. Methods: 60 cases of 2016 years in October 2017 to March 2017 in our hospital admissions of elderly osteoporotic thoracolumbar vertebral compression fractures, according to the random number table method is divided into experimental group and control group, each group of 30 cases, are given conventional On the basis of drug treatment, the control group was given conservative treatment such as reduction pillow and rehabilitation training, and the experimental group was treated by percutaneous vertebroplasty. Results: Before treatment, the levels of serum MMP-3, TIMP-1 and IL-6 were not significantly different between the two groups (P> 0.05). After treatment, the levels of serum MMP-3 and IL-6 were decreased (P <0.05). Before treatment, There was no significant difference in VAS score between the two groups (P> 0.05). After 1 week of treatment and after treatment, the VAS score of the experimental group was lower than that of the control group (P <0.05), Before treatment, there was no difference in Cobb angle between the two groups (P> 0.05), after treatment, the Cobb angle of the two groups was significantly lower than that of the control group (P> 0.05). There was no significant difference in the height ratio between the two groups before treatment (P> 0.05), After treatment, the height of the two groups was significantly lower than that of the control group (P <0.05). After treatment, The effective rate was 96.67% in the experimental group and 76.67% in the control group, the difference was significant (P <0.05). Conclusion: Percutaneous vertebroplasty can effectively reduce the levels of serum MMP-3 and IL-6 and restore the level of TIMP-1, which can significantly improve the treatment of osteoporotic thoracolumbar vertebrae compression fractures .