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Glucose-Dependent Granule Docking Limits Insulin Secretion and Is Decreased in Human Type 2 Diabetes
Authors:Nikhil R. Gandasi  Peng Yin  Muhmmad Omar-Hmeadi  Emilia Ottosson Laakso  Petter Vikman  Sebastian Barg
Affiliation:1. Department of Medical Cell Biology, Uppsala University, BMC 571, 75123 Uppsala, Sweden;2. Diabetes and Endocrinology Unit, Department of Clinical Sciences, Lund University Diabetes Centre, 20502 Malmö, Sweden
Abstract:
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  • Keywords:insulin secretion  exocytosis  type 2 diabetes  dense core vesicle  docking  priming  biphasic secretion  genome-wide association  GLP-1  somatostatin
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