| 注意缺损多动障碍关联于DXS7位点
Association of Attention-Deficit Hyperactivity Disorder and the DXS7 Locus |
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| 引用本文： | 江三多,忻仁娥,林嗣萃,钱伊萍,江开达,任大明,汤国梅,汪栋祥,严和骏JIANG San-DuoXIN Ren-ELIN Si-CuiQIAN Yi-PingJIANG Kai-DaREN Da-MingTANG Guo-MeiWANG Dong-XangYAN He-Jun.注意缺损多动障碍关联于DXS7位点
Association of Attention-Deficit Hyperactivity Disorder and the DXS7 Locus[J].遗传,1999,21(2):7-615. |
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| 作者姓名： | 江三多 忻仁娥 林嗣萃 钱伊萍 江开达 任大明 汤国梅 汪栋祥 严和骏JIANG San-DuoXIN Ren-ELIN Si-CuiQIAN Yi-PingJIANG Kai-DaREN Da-MingTANG Guo-MeiWANG Dong-XangYAN He-Jun |
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| 作者单位： | 1.上海市精神卫生中心，上海200030
2.上海医科大学精神医学教研室，上海200032
3.复旦大学遗传研究所，上海200433
1.Shanghai Mental Health Center,Shanghai200030
2.Department of Mental Health,Shanghai Medical University,Shanghai200032
3.Genetics Institute,Fudan University,Shanghai200433 |
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| 摘 要： | 采用单体型相对风险和传递/不平衡检验方法，在中国人群中对注意缺损多动障碍（ADHD）与DXS7位点进行了遗传关联分析。结果表明，以父母双亲为对照，DXS7位点157bp等位基因与ADHD具有显著关联(χ2=9.10, P<0.05)并连锁(χ2=9.53, P<0.05)。提示，ADHD关联和连锁于DXS7位点。
Abstract The present study was designed to assess the genetic association between attention-deficit hyperactivity disorder(ADHD) and DXD7 locus polymorphism in Chinese population, with haplotype-based haplotype relative risk(HHRR) and the transmission/disequilibrium test(TDT) analysis. We found significant association(χ2=9.10, P<0.05) and linkage (χ2=9.53, P<0.05) between the 157bp DXS7 allele and DSM-Ⅲ-R-diagnosed ADHD(N=54) in trios composed of father, mother and affected offspring. Our results suggest that ADHD was associated and in linkage with DXS7 locus.
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| 关 键 词： | 注意缺损多动障碍 DXS7位点 关联 连锁 Key words ADHD DXS7 locus |
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