FOXP3+ Lymphocyte Density in Pancreatic Cancer Correlates with Lymph Node Metastasis |
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| Authors: | Yongjian Jiang Zunguo Du Feng Yang Yang Di Ji Li Zhongwen Zhou Venu G. Pillarisetty Deliang Fu |
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| Affiliation: | 1. Department of Pancreatic Surgery, Huashan Hospital, Fudan University, Shanghai, China.; 2. Department of Pathology, Huashan Hospital, Fudan University, Shanghai, China.; 3. Department of Surgery, University of Washington, Seattle, Washington, United States of America.; Centro di Riferimento Oncologico, IRCCS National Cancer Institute, Italy, |
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| Abstract: | ObjectiveTo determine if the density of FOXP3+ lymphocytes in primary tumors and lymph nodes in pancreatic cancer correlates with the presence of lymph node metastases.MethodsFOXP3+ lymphocyte density in primary pancreatic cancer tissue and draining lymph nodes was measured using immunohistochemistry. We analyzed the clinical and pathological aspects associated with the accumulation of FOXP3+ lymphocytes in pancreatic cancer. We also analyzed the correlation of density of FOXP3+ lymphocytes in lymph nodes with the nodal status and distance from the primary tumor.ResultsFOXP3+ lymphocyte density in pancreatic cancer was significantly higher than in paratumoral pancreatic tissue. The density of FOXP3+ lymphocytes in local tumor tissue correlated significantly with the histological grade and overall lymph node status. Furthermore, FOXP3+ lymphocyte density was significantly higher in positive lymph nodes than in negative ones, while it had no correlation with the distance of the lymph node from the primary tumor.ConclusionFOXP3+ lymphocyte density in primary tumor tissue in patients with pancreatic cancer correlates with lymph node metastasis. Lymph nodes containing metastases having higher FOXP3+ lymphocyte densities than do negative lymph nodes. |
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