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Modeling Rett syndrome with stem cells
Authors:Walsh Ryan M  Hochedlinger Konrad
Affiliation:Howard Hughes Medical Institute at Massachusetts General Hospital, Center for Regenerative Medicine and Cancer Center, Boston, MA 02114, USA.
Abstract:
The discovery that somatic cells can be reprogrammed into induced pluripotent stem cells (iPSCs) raised the exciting possibility of modeling diseases with patient-specific cells. Marchetto et?al. (2010) now use iPSC technology to generate, characterize, and treat an in?vitro model for the autism spectrum disorder Rett syndrome.
Keywords:
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