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Localisation of the gene for Norrie disease to between DXS7 and DXS426 on Xp
Authors:S. Lindsay  D. L. Thiselton  J. B. Bateman  J. T. Ngo  R. S. Sparkes  M. Coleman  K. E. Davies  S. S. Bhattacharya
Affiliation:(1) Molecular Genetics Unit, Division of Human Genetics, University of Newcastle-upon-Tyne, NE2 4AA Newcastle-upon-Tyne, UK;(2) Jules Stein Eye Institute, UCLA School of Medicine, 90024-1771 Los Angeles, CA, USA;(3) Vision Genetics Center, UCLA School of Medicine, 90024-1771 Los Angeles, CA, USA;(4) Department of Medicine and Pediatrics, UCLA School of Medicine, 90024-1771 Los Angeles, CA, USA;(5) Molecular Genetics Group, Institute of Molecular Medicine, John Radcliffe Hospital, OX3 9DU Oxford, UK
Abstract:
Summary A highly informative microsatellite marker, DXS426, which maps proximal to DXS7 in the interval Xp11.4–Xp11.23, has been used to refine further the localisation of the gene for Norrie disease (NDP). The results from a multiply informative crossover localize the NDP gene proximal to DXS7. In conjunction with information from 2 NDP patients who have a deletion for DXS7 but not for DSX426, our data indicate that the NDP gene lies between DXS7 and DXS426 on proximal Xp.
Keywords:
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