3,5-dibenzoyl-1,4-dihydropyridines: synthesis and MDR reversal in tumor cells |
| |
Authors: | Kawase Masami Shah Anamik Gaveriya Harsukh Motohashi Noboru Sakagami Hiroshi Varga Andreas Molnár Joseph |
| |
Institution: | Faculty of Pharmaceutical Sciences, Josai University, 350-0295, Saitama, Japan. kawasema@josai.ac.jp |
| |
Abstract: | Fifteen 4-phenyl-3,5-dibenzoyl-1,4-dihydropyridines (BzDHPs) (1-15) substituted at the 4-phenyl ring were synthesized and compared to their cytotoxic activity and multidrug resistance (MDR)-reversing activity in in vitro assay systems. Among them, 2-CF3 (5) (IC50=8.7 microM), 2-Cl (11) (IC50=7.0 microM) and 3-Cl (12) (IC50=7.0 microM) derivatives showed the highest cytotoxic activity against human oral squamous carcinoma (HSC-2) cells. The activity of P-glycoprotein (Pgp) response for MDR in tumor cells was reduced by some of derivatives (3, 4, 8, 12), verapamil (VP) and nifedipine (NP). These data suggest that 3,5-dibenzoyl-4-(3-chlorophenyl)-1,4-dihydro-2,6-dimethylpyridine (12) can be recommended as a new drug candidate for MDR cancer treatment. |
| |
Keywords: | |
本文献已被 ScienceDirect PubMed 等数据库收录! |
|