In vitro induction of the graft-versus-host reaction |
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| Authors: | R Auerbach A Globerson |
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| Affiliation: | 1. Department of Immunology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;2. Department of Cardiology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran;1. Division of Hematology, Department of Medicine, Brigham and Women''s Hospital, Harvard Medical School, Boston, MA;;2. Human Oncology and Pathogenesis Program, Memorial Sloan-Kettering Cancer Center, New York, NY; and;3. Broad Institute, Cambridge, MA;1. Graduate Program in Molecular, Cellular and Integrative Bioscience, Penn State University, University Park, PA;2. Center for Molecular Immunology and Infectious Disease, Penn State University, University Park, PA;3. Graduate Program in Biochemistry, Microbiology and Molecular Biology, Penn State University, University Park, PA;4. Atreca Inc., Redwood City, CA;5. Graduate Program in Pathobiology, Penn State University, University Park, PA;6. Center for Molecular Toxicology and Carcinogenesis, Penn State University, University Park, PA;7. Department of Veterinary and Biomedical Sciences, Penn State University, University Park, PA;8. Department of Biology, Penn State University, University Park, PA |
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| Abstract: | ![]()
- 1.1. Using an in vitro method of analysis, the graft-versus-host reaction in mice has been studied.
- 2.2. Previous observations made in vivo for graft-versus-host reactions, including timing of the onset of immunological maturity and the effects of irradiation, have been confirmed in this in vitro system.
- 3.3. The host component of the graft-versus-host reaction has been analyzed by use of an intervening millipore filter barrier. Splenomegaly and associated histological changes can be induced in the absence of actual entry of adult spleen cells into the explanted test fragment.
- 4.4. Additional experiments involving quantitative aspects of the reaction are described.
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