Cyathuscavins A, B, and C, new free radical scavengers with DNA protection activity from the Basidiomycete Cyathus stercoreus |
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| Authors: | Kang Hahk-Soo Kim Kyoung-Rok Jun Eun-Mi Park Soon-Hye Lee Tae-Soo Suh Joo-Won Kim Jong-Pyung |
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| Institution: | aKorea Research Institute of Bioscience and Biotechnology, Functional Metabolite Research Center, 52 Eoeun-dong, Yuseong, Daejeon 305-806, Republic of Korea;bDepartment of Biological Science, Division of Bioscience and Bioinformatics, Myongji University, Yongin 449-728, Republic of Korea;cDepartment of Biology, University of Incheon, Incheon 402-709, Republic of Korea |
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| Abstract: | Three new polyketides, cyathuscavins A (1), B (2), and C (3) were isolated from the mycelium culture of Cyathus stercoreus. The structures of the compounds were elucidated on the basis of NMR and mass spectroscopic data. Antioxidant activities of the compounds were evaluated by the scavenging ability against ABTS+, DPPH, and superoxide anion radicals. Cyathuscavins A–C showed significant antioxidant activity comparable to those of reference antioxidants, BHA and Trolox. Cyathuscavins A–C protected supercoiled plasmid DNA from Fe2+/H2O2-induced breakage. |
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| Keywords: | Cyathus stercoreus DNA protection Free radical scavenger Polyketide |
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