辅酶Q_(10)的毒性试验及对溶血空斑形成细胞的刺激效应

辅酶Q_10（以下简称CoQ_(10)）是生物体内普遍存在的一类生物活性物质,具有重要的生理、生化作用。它是细胞呼吸链中主要的递氢体,在生物能量转化中占重要地位,它又能作为非特异性免疫增强剂,增强机体的防御能力,因此人们对于CoQ_(10)的临床研究越来越受到重视（中国科学院昆明动物研究所,1979）。 我们结合我国具体情况,独创地从提取细胞色素丙的猪心残渣中分离制备了CoQ_(10), （许以盛等,1985）,并与有关生产及临床单位协作,于1977年12月通过了鉴定,为我国的生化药物填补了一项空白。

TOXICITY STUDY ON CoQ_(10) AND ITS STIMULANT EFFECT ON THE FORMATION OF PLAQUE-FORMING CELLS

The acute toxicity test in mice shows that the LD60 of CoQ10 administered i.p. is above 500 mg/kg. The subacute toxicity test in dogs leads us to the conclusion that CoQ10 administered i.p., 60 mg/dog, daily for 15 days causes no significant adverse effects on their general conditions, haematological and biochemical indices. Autopsy and histological examinations also show no significant pathological changes in hearts, livers, lungs, spleens and kidneys in treated dogs. When administered i.p., 20 mg/kg and 10 mg/kg, CoQ10 increase the formation of plaque-forming cells in murine spleens by 0.49 and 0.41 respectively. The possibility of clinical applications of CoQ10 suggested by our results are discussed.