Short term effects of dexamethasone on hyaluronidase activity and sperm characteristics in rams |
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| Institution: | 1. Department of Informatics, Ionian University, Corfu, Greece;2. Institut National de la Recherche Scientifique (INRS-EMT), University of Quebec, Montreal, QC, Canada;1. Institut d’Investigació per a la Gestió Integrada de les Zones Costaneres (IGIC), Universitat Politècnica de València, C/ Paranimf 1, Gandia 46730, Spain;2. GRPHE - Université de Haute Alsace - Institut universitaire de technologie de Colmar, 34 rue du Grillenbreit BP Colmar 50568 - 68008, France;3. Technical University of Catalonia, Laboratory of Applied Bioacoustics, Rambla Exposició,08800 Vilanova i la Geltrú, Barcelona, Spain;4. Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen Centre for Astroparticle Physics, Erwin-Rommel-Str. 1, Erlangen 91058, Germany;5. CPPM, Aix-Marseille Université, CNRS/IN2P3, CPPM UMR 7346, Marseille, 13288, France;6. APC, Université Paris Diderot, CNRS/IN2P3, CEA/IRFU, Observatoire de Paris, Sorbonne Paris Cité, Paris, 75205, France;7. IFIC - Instituto de Fsica Corpuscular, Parque Cientfico, C/Catedrtico Jos Beltrn 2, Paterna E-46980, Spain;8. LAM - Laboratoire d’Astrophysique de Marseille, Pôle de l’Étoile Site de Château-Gombert, rue Frédéric Joliot-Curie 38, Marseille Cedex 13 13388, France;9. INFN - Sezione di Bologna, Viale Berti-Pichat 6/2, Bologna 40127, Italy;10. Dipartimento di Fisica e Astronomia dell’Università, Viale Berti Pichat 6/2, Bologna 40127, Italy;11. Nikhef, Science Park, Amsterdam, The Netherlands;12. Huygens-Kamerlingh Onnes Laboratorium, Universiteit Leiden, The Netherlands;13. Universiteit van Amsterdam, Instituut voor Hoge-Energie Fysica, Science Park 105, 1098 XG Amsterdam, The Netherlands;14. INFN -Sezione di Roma, P.le Aldo Moro 2, Roma 00185, Italy;15. Dipartimento di Fisica dell’Università La Sapienza, P.le Aldo Moro 2, Roma 00185, Italy;p. Institute for Space Science, Bucharest RO-077125, Măgurele, Romania;q. INFN - Sezione di Bari, Via E. Orabona 4, Bari 70126, Italy;r. INFN - Laboratori Nazionali del Sud (LNS), Via S. Sofia 62, Catania 95123, Italy;s. Mediterranean Institute of Oceanography (MIO), Aix-Marseille University, Cedex 9, Marseille,13288, France;t. Universit du Sud Toulon-Var, 83957, La Garde Cedex, CNRS-INSU/IRD UM 110, France;u. Géoazur, Université Nice Sophia-Antipolis, CNRS, IRD, Observatoire de la Côte d’Azur, Sophia Antipolis, France;v. Univ. Paris-Sud, Orsay Cedex 91405, France;w. Laboratoire de Physique Corpusculaire, Clermont Univertsité, Université Blaise Pascal, CNRS/IN2P3, BP 10448, Clermont-Ferrand F-63000, France;x. Institut für Theoretische Physik und Astrophysik, Universität Würzburg, Emil-Fischer Str. 31, Wrzburg 97074, Germany;y. NFN - Sezione di Pisa, Largo B. Pontecorvo 3, Pisa 56127, Italy;z. Dipartimento di Fisica dell’Università, Largo B. Pontecorvo 3, Pisa 56127, Italy;1. INFN - Sezione di Catania, Viale Andrea Doria 6, Catania 95125, Italy;2. Royal Netherlands Institute for Sea Research (NIOZ), Landsdiep 4,1797 SZ ’t Horntje (Texel), The Netherlands;3. INFN - Sezione di Genova, Via Dodecaneso 33, Genova 16146, Italy;4. Dipartimento di Fisica dell Universita, Via Dodecaneso 33, Genova 16146, Italy;5. Universiteit Utrecht, Faculteit Betawetenschappen, Princetonplein 5, CC Utrecht 3584, The Netherlands;6. Dr. Remeis-Sternwarte and ECAP, Universität Erlangen-Nürnberg, Sternwartstr. 7, 96049 Bamberg, Germany;7. Moscow State University, Skobeltsyn Institute of Nuclear Physics, Leninskie gory, Moscow 119991, Russia;8. Dipartimento di Fisica ed Astronomia dell Universita, Viale Andrea Doria 6, 95125 Catania, Italy;9. Direction des Sciences de la Matière - Institut de recherche sur les lois fondamentales de l’Univers - Service de Physique des Particules, CEA Saclay, 91191 Gif-sur-Yvette Cedex, France;10. INFN -Sezione di Napoli, Via Cintia Napoli 80126, Italy;11. University Mohammed I, Laboratory of Physics of Matter and Radiations, B.P.717, Oujda 6000, Morocco;12. IPHC-Institut Pluridisciplinaire Hubert Curien - Université de Strasbourg et, CNRS/IN2P3 23 rue du Loess, BP 28, Strasbourg Cedex 2 67037, France;13. ITEP - Institute for Theoretical and Experimental Physics, B. Cheremushkinskaya 25, Moscow 117218, Russia;14. Dipartimento di Fisica dell Universita Federico II di Napoli, Via Cintia 80126, Napoli, Italy |
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| Abstract: | The aim of this study was to determine the effects of dexamethasone on sperm characteristics and hyaluronidase activity of serum and semen. In this investigation, 14 healthy Akkaraman rams, at the age of 2 years and weighing between 50–60 kg, were used. The rams were randomly divided into two groups. After the last administration of dexamethasone intramuscularly at a dose of 0.25 mg/kg, semen and blood samples were taken at different times. The results showed that the serum hyaluronidase activity was increased significantly (p < 0.001) in the treatment group when compared with the control group except for the 1st hour. There was a significant difference (p < 0.001, 0.01, 0.05) in the hyaluronidase activity of semen between the treatment group and the control group. Furthermore, there was a significant difference (p < 0.01) in sperm concentration between both groups at all the times except the 96th hour. There were statistically significant (p < 0.05) differences in semen volume between the treatment and control groups. There were also significant differences (p < 0.05) in sperm motility between the treatment and control groups except for the 72 and 96th hours.These findings indicate that dexamethasone increases hyaluronidase activity of serum and semen, but it decreases sperm concentration, semen volume and sperm motility in rams. Therefore the use of these drugs in breeding rams during breeding season is not suitable. |
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