A human-derived probe,p82H,hybridizes to the centromeres of gorilla,chimpanzee, and orangutan |
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| Authors: | Dorothy A Miller Vasundhara Sharma Arthur R Mitchell |
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| Institution: | (1) Department of Molecular Biology and Genetics, Wayne State University, 540 East Canfield, 48201 Detroit, MI, USA;(2) Present address: MRC Clinical and Population Cytogenetics Unit, Western General Hospital, Crewe Road, Edinburgh, UK |
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| Abstract: | A human-derived centromeric sequence, p82H, hybridizes to DNA from gorilla, chimpanzee, pygmy chimpanzee, and orangutan. On DNA blots, multimeric ladders based on 170 or 340 bp repeat units are seen. In metaphase chromosome preparations from these species, p82H hybridizes to the centromeric region of every chromosome. p82H forms less stable hybrids with DNA from the lion-tailed macaque and does not hybridize to DNA or chromosomes of the owl monkey or the mouse. |
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