Identification and Distribution of Phenylacetic Acid in the Brain of the Rat |
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| Authors: | David A Durden Alan A Boulton |
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| Institution: | Psychiatric Research Division, University Hospital, Saskatoon, Saskatchewan, Canada |
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| Abstract: | Abstract: Phenylacetic acid, the major metabolite of phenylethylamine, has been identified and quantitated in rat brain regions by capillary column high-resolution gas chromatography mass spectrometry. Its distribution is heterogeneous and correlates with that of phenylethylamine. The values obtained were (ng/g ± SEM): whole brain, 31.2 ± 2.7; caudate nucleus, 64.6 ± 6.5; hypothalamus, 60.1 ± 7.4; cerebellum, 31.3 ± 2.9; brainstem, 33.1 ± 3.3, and the "rest," 27.6 ± 3.0. |
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| Keywords: | Phenylacetic acid Phenylethylamine metabolite Trace amine metabolites GC-MS analysis |
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