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Excessive Cell Growth Causes Cytoplasm Dilution And Contributes to Senescence
Authors:Gabriel E Neurohr  Rachel L Terry  Jette Lengefeld  Megan Bonney  Gregory P Brittingham  Fabien Moretto  Teemu P Miettinen  Laura Pontano Vaites  Luis M Soares  Joao A Paulo  J Wade Harper  Stephen Buratowski  Scott Manalis  Folkert J van Werven  Liam J Holt  Angelika Amon
Institution:1. David H. Koch Institute for Integrative Cancer Research, Howard Hughes Medical Institute, Massachusetts Institute of Technology, Cambridge, MA 02139, USA;2. Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139, USA;3. Department of Systems Biology, Harvard Medical School, Boston, Massachusetts 02115, USA;4. Institute for Systems Genetics, New York University Langone Health, New York, NY 10016, USA;5. Cell Fate and Gene Regulation Laboratory, The Francis Crick Institute, 1 Midland Road, NW1 1AT London, UK;6. David H. Koch Institute for Integrative Cancer Research, Massachusetts Institute of Technology, Cambridge, MA 02139, USA;7. Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA;8. Department of Mechanical Engineering, Massachusetts Institute of Technology, Cambridge, MA 02139, USA;9. Department of Cell Biology, Harvard Medical School, Boston, MA 02115, USA;10. Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115, USA;11. MRC Laboratory for Molecular Cell Biology, University College London, Gower Street, London, WC1E 6BT, UK;12. Novartis Institute for Biomedical Research, Oncology Department, Cambridge, MA 02139
Abstract:
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