Trapped in a vicious loop: Toll-like receptors sustain the spontaneous cytokine production by rheumatoid synovium |
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Authors: | Shahla Abdollahi-Roodsaz Fons AJ van de Loo Wim B van den Berg |
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Institution: | (1) Rheumatology Research and Advanced Therapeutics, Department of Rheumatology, Radboud University Nijmegen Medical Centre, PO Box 9101, 6500, HB, Nijmegen, The Netherlands |
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Abstract: | Synovial tissue of patients with rheumatoid arthritis (RA) spontaneously produces several cytokines, of which a fundamental
role in joint inflammation and destruction has been established. However, the factors sustaining this phenomenon remain poorly
understood. In a recent report, blockade of Toll-like receptor 2 (TLR2) was found to inhibit the spontaneous release of inflammatory
cytokines by intact RA synovial explant cultures. Adding to the recent evidence implicating other TLRs (in particular, TLR4),
this observation highlights the potential of TLRs as therapeutic targets to suppress the local production of multiple cytokines
and to control the chronic inflammatory loop in RA. |
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Keywords: | |
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