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G-6-PD Jalisco and G-6-PD Morelia: Two new Mexican variants |
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| Authors: | G Vaca B Ibarra D García Cruz C Medina F Romero J M Cantú E Beutler |
| Institution: | (1) División de Genética, Subjefatura de Investigación Científica, Unidad de Investigación Biomédica, Centro Médico de Occidente, Instituto Mexicano del Seguro Social, Apartado Postal 1-3838, Guadalajara, Jalisco, Mexico;(2) Centro Médico de Occidente, Instituto Mexicano del Seguro Social, Hospital de Especialidades, Guadalajara, Jalisco, Mexico;(3) Department of Basic and Clinical Research, Scripps Clinic and Research Foundation, La Jolla, California, USA |
| Abstract: | Summary Two new G-6-PD variants designated G-6-PD Jalisco and G-6-PD Morelia were identified in two unrelated Mexican families. An additional G-6-PD variant was found in each family: G-6-PD trinacria and G-6-PD A-. In both families compound heterozygotes were identified. G-6-PD Jalisco and G-6-PD Morelia belong to Classes 3 and 4, respectively. G-6-PD Morelia is the first variant from its class with a high Km for NADP and a low Ki for NADPH. |
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