Neoplastic association of enhanced type V collagen production in rat fibrosarcoma |
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| Authors: | R. Asokan G. Kesava Reddy S. C. Dhar |
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| Affiliation: | (1) Department of Biochemistry, Central Leather Research Institute, 600 020 Madras, India;(2) Present address: Department of Biochemistry, University of Georgia, 30602 Athens, GA, USA;(3) Present address: Department of Biochemistry and Molecular Biology, The University of Kansas Medical Center, 3901 Rainbow Blvd., 66160 Kansas City, KS, USA |
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| Abstract: | ![]()
Collagens present in the connective tissues of the extracellular matrix of fibrosarcoma were isolated and characterized. The fibrosarcoma was induced in rats by the administration of 3-methylcholanthrene. The results obtained were compared with normal muscle. An excess amount of type V collagen was found to be produced by the fibrosarcoma tissue compared to the normal muscle. Type V collagen from fibrosarcoma was characterized on the basis of solubility behavior in sodium chloride solutions, electrophoretic mobility on SDS-polyacrylamide gels, elution pattern of phosphocellulose chromatography and amino acid composition. |
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| Keywords: | extracellular matrix collagen fibrosarcoma |
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