前列地尔联合丹红注射液治疗糖尿病周围神经病变的疗效分析

目的：探讨前列地尔联合丹红注射液治疗糖尿病周围神经病变的效果，为治疗糖尿病周围神经病变提供临床依据。方法：采用回顾性调查的方法，选取我院2011年1月-2012年12月收治的糖尿病周围神经病变150例，分为前列地尔联合丹红注射液组（联合治疗组），前列地尔组和丹红组，每组各50例。结果：联合治疗组总有效率为94．00％（47／50），高于丹红组86．00％（43／50）和前列地尔组88．00％（44／50）（P〈0．05）；联合治疗组显效率为68．00％（34／50），高于丹红组60．00％（30／50）和前列地尔组60．00％（30／50）；联合治疗组无效率为9．00％（3／50），低于丹红组14．00％（7／50）和前列地尔组12．00％（6／50）（P〈0．05）；三组治疗后正中神经和腓总神经MNCV和SNCV均高于治疗前，差异有统计学意义（P〈0．05）；联合治疗组治疗后均高于丹红组和前列地尔组治疗后，差异有统计学意义（P〈0．05）。结论：前列地尔联合丹红注射液可有效提高正中神经和腓总神经MNCV和SNCV，对改善糖尿病周围神经病变效果较好。

Clinical Analysis of the Alprostadil Combined with Danhong for the Treatment of Diabetic Peripheral Neuropathy

Objective： To investigate the clinical effect of alprostadil combined with Danhong injection for diabetic peripheral neuropathy, and to provide the clinical basis for the clinical field. Methods： A retrospective analysis was conducted about 150 patients with the diabetic peripheral neuropathy who were treated in our hospital from January 2011 to December 2012, which were divided into alprostadil combined with Danhong injection group （combined treatment group）, alprostadil group and Danhong group, each groups of 50 patients. Results： The total effective rate of combined treatment group was 94% （47/50） which was higher than those of the Danhong group 86% （43/50） and the alprostadil group 88% （44/50） （P 〈 0.05）; The effective rate of combined treatment group was 68% （34/50） which was higher than those of the Danhong group 60% （30/50） and the alprostadil group 60% （30/50）; The invalid rate of combined treatment group was 9% （3/50） which was lower than those of the Danhong group 14% （7/50） and the alprostadil group 12% （6/50） （P 〈 0.05）; After they were treated ,MNCV and SNCV of median nerve and common peroneal nerve in three groups were higher than those of pre-treatment, the difference has statistical significance （P 〈 0.05）; After they were treated, MNCV and SNCV of median nerve and common peroneal nerve of combined treatment group were higher than those of epalrestat group and alprostadil group, and the difference was statistically significant （P 〈 0.05）. Conclusion： Alprostadil combined with Danhong injection can effectively improve MNCV and SNCV of the median nerve and common peroneal nerve, and the treatment effect was better than that of alprostadil injection combined or Danhong injection.