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Characterization and evolution of major histocompatibility complex class II genes in the aye-aye, Daubentonia madagascariensis |
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| Authors: | Yasuhiro Go Gilbert Rakotoarisoa Yoshi Kawamoto Taizo Shima Naoki Koyama Albert Randrianjafy Roger Mora Hirohisa Hirai |
| Institution: | (1) Department of Biosystems Science, The Graduate University for Advanced Studies (Sokendai), Hayama, Kanagawa, 240-0193, Japan;(2) Primate Research Institute, Kyoto University, Inuyama, Aichi, Japan;(3) Parc Botanique et Zoologique de Tsimbazaza, Antananarivo, Madagascar;(4) Aye-aye Conservation Project, Japan Aye-aye fund, Japan;(5) Center for African Area Studies, Kyoto University, Kyoto, Japan;(6) Ivoloina Zoological Park, Madagascar |
| Abstract: | Major histocompatibility complex genes (Mhc-DQB and Mhc-DRB) were sequenced in seven aye-ayes (Daubentonia madagascariecsis), which is an endemic and endangered species in Madagascar. An aye-aye from a north-eastern population showed genetic relatedness to individuals of a north-western population and had a somewhat different repertoire from another north-eastern individual. These observations suggest that the extent of genetic variation in Mhc genes is not excessively small in the aye-aye in spite of recent rapid destruction of their habitat by human activities. In light of Mhc gene evolution, trans-species and allelic polymorphisms can be estimated to have been retained for more than 50 Ma (million years) based on the time scale of lemur evolution. |
| Keywords: | Aye-aye Conservation Evolution Madagascar Major histocompatibility complex |
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