| 链霉菌聚酮类次生代谢产物及其生物合成基因簇 |
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| 引用本文： | 陈敏捷,王广华,戴世鲲,谢练武,李翔.链霉菌聚酮类次生代谢产物及其生物合成基因簇[J].微生物学报,2009,49(12):1555-1563. |
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| 作者姓名： | 陈敏捷 王广华 戴世鲲 谢练武 李翔 |
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| 作者单位： | 1. 中国科学院南海海洋研究所,广州,510301中国科学院研究生院,北京,100409
2. 中国科学院南海海洋研究所,广州,510301 |
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| 基金项目： | 中国科学院创新项目（07YZ075001，07YZ073001）；中国科学院引进国外杰出人才计划（06YB011001） |
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| 摘 要： | 摘要：聚酮类抗生素在工业、农业和医药方面都具有重要的商业价值，至今通过美国FDA认证的聚酮类药物超过40个。随着分子生物学的发展，人们开展了抗生素合成基因簇的研究，并以此为基础发展了组合生物学，形成天然产物化学与分子生物学相结合的跨学科研究领域。本文以链霉菌为对象，对链霉菌产生的聚酮类抗生素的药物应用、聚酮合成酶（PKS）的研究及聚酮类药物的开发策略与前景作了相关介绍。
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| 关 键 词： | 关键词：链霉菌 聚酮类抗生素 Polyketide Synthase（PKS） |
| 收稿时间： | 2009/5/15 0:00:00 |
| 修稿时间： | 6/1/2009 12:00:00 AM |
Polyketide antibiotics produced by polyketide synthase in streptomyces-A review |
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| Minjie Chen,Guanghua Wang,Shikun Dai,Lianwu Xie and Xiang Li.Polyketide antibiotics produced by polyketide synthase in streptomyces-A review[J].Acta Microbiologica Sinica,2009,49(12):1555-1563. |
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| Authors: | Minjie Chen Guanghua Wang Shikun Dai Lianwu Xie and Xiang Li |
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| Institution: | South China Sea Institute of Oceanology, Chinese Academy of Science, Guangzhou 510301, China;South China Sea Institute of Oceanology, Chinese Academy of Science, Guangzhou 510301, China;South China Sea Institute of Oceanology, Chinese Academy of Science, Guangzhou 510301, China;South China Sea Institute of Oceanology, Chinese Academy of Science, Guangzhou 510301, China;South China Sea Institute of Oceanology, Chinese Academy of Science, Guangzhou 510301, China |
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| Abstract: | Abstract: Polyketides have played an important role in antibiotic drug discovery with most antibacterial drugs being derived from a natural product or natural product lead. Furthermore, the biosynthetic gene clusters for numerous bioactive polyketides have been intensively studied over the past 15 years. This paper focuses on the polyketide drugs approved by US-FDA and takes a general view in the antibiotics produced by polyketide synthase in streptomyces. |
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| Keywords: | Keywords: streptomyces polyketide antibiotics polyketide synthase |
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