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In vitro drug permeation from chitosan pellets |
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| Authors: | Priscileila C FerrariFagner M Souza Leandro GiorgettiGiselle F Oliveira Marco V ChaudHumberto G Ferraz Raul C Evangelista |
| Institution: | a Department of Drugs and Pharmaceuticals, School of Pharmaceutical Sciences, Universidade Estadual Paulista - UNESP, Rodovia Araraquara-Jaú, km 1, CEP 14801-902 Araraquara, SP, Brazil b Department of Pharmacy, School of Pharmaceutical Sciences, São Paulo University - USP, Avenida Professor Lineu Prestes, 580, Bloco 13, CEP 05508-000 São Paulo, SP, Brazil c Pharmaceutical Sciences Post-Graduate Program, Sorocaba University, Rodovia Raposo Tavares, Km 92.5, CEP 18023-000 Sorocaba, SP, Brazil |
| Abstract: | The purpose of this study was to prepare and characterize coated pellets for controlled drug delivery. The influence of chitosan (CS) in pellets was evaluated by swelling, in vitro drug release and intestinal permeation assays. Pellets were coated with an enteric polymer, Kollicoat® MAE 30 DP, in a fluidized-bed apparatus and the coating formulations were based on a factorial design. Metronidazole (MT) released from coated and uncoated pellets were assessed by dissolution method using Apparatus I. Intestinal permeation was evaluated by everted intestinal sac model in rats, used to study the absorption of MT from coated pellets containing CS or not through the intestinal tissue. Although the film coating avoided drug dissolution in gastric medium, the overall drug release and intestinal permeation were dependent on the presence of CS. Thus, pellets containing CS show potential as a system for controlled drug delivery. |
| Keywords: | Pellets Chitosan Enteric coating Metronidazole Controlled drug delivery Everted intestinal sac model |
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