| 神经生长因子对大鼠视觉诱发电位的影响 |
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| 作者姓名： | Huang CG Wei SJ Jiang H Song SK |
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| 作者单位： | 上海第二军医大学基础部, |
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| 摘 要： | 目的和方法：本研究主要通过电生理方法，测定经CS2所致视神经损害的大鼠在治疗前后视觉诱发电位的变化，以证实神经生长因子对受损神经的治疗效果。结果：大鼠视神经损伤模型经神经生长因子治疗20d后，模式反转诱发电位和闪光诱发电位的潜伏期与对照组相比均有明显的缩短，并有量－效关系。结论：神经生长因子能明显改善视神经传导功能，提示神经生长因子对视神经损伤有一定的治疗作用。
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| 关 键 词： | 神经生长因子 模式释转电位 闪光诱发电位 视神经损伤 视觉诱发电位 |
| 文章编号： | 1000-6834(2001)04-0349-03 |
| 修稿时间： | 2000年3月27日 |
Effect of nerve growth factor on the visual evoked potential of rats pretreated by CS2 |
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| Huang CG,Wei SJ,Jiang H,Song SK.Effect of nerve growth factor on the visual evoked potential of rats pretreated by CS2[J].Chinese Journal of Applied Physiology,2001,17(4):349-351. |
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| Authors: | Huang C G Wei S J Jiang H Song S K |
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| Institution: | Department of Basic Medicine, Second Military Medical University, Shanghai 200433, China. |
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| Abstract: | Aim: To study the therapeutic effect of NGF to rats with newly CS 2 deranged. Methods: The model of rats with deranged visual nerve was made by CS 2(i.p) for three weeks. Rats were then treated with different dosages of NGF for three weeks, and the changes of visual evoked potential were determined. Results: The latency of PREP and FEP shortened significantly vs control after treatment for 10 and 20 days.Conclusion: NGF can improve the conductivity of visual with dose effect relationship, suggesting that NGF has a significant therapeutic effect on the deranged visual nerve. |
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| Keywords: | NGF PREP FEP deranged visual nerve |
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