| 干扰素诱导蛋白p204调节心肌分化的机制及应用前景 |
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| 引用本文： | 宋方,吴强.干扰素诱导蛋白p204调节心肌分化的机制及应用前景[J].细胞生物学杂志,2011(1). |
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| 作者姓名： | 宋方 吴强 |
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| 作者单位： | 贵州省心血管病研究所贵州省人民医院心内科; |
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| 基金项目： | 贵州省优秀科技教育人才省长专项资金(No.黔省专合字[2009]30号)资助项目~~ |
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| 摘 要： | 干扰素诱导蛋白p200家族蛋白包括6种鼠类及4种人类家族成员,具有共同的特征结构,广泛参与调节细胞增殖和分化、衰老和凋亡,在自身免疫反应、抗病毒及抗癌等领域发挥着重要的作用。内源性的p200家族蛋白鼠p204在心肌及骨骼肌表达最高,提示其在肌分化中起着重要作用。本文联系p204的分子结构及调节细胞生长与分化的功能,阐述p204促骨骼肌成肌细胞及胚胎癌细胞分化的机制,及对心肌损伤后心肌再生的应用前景。
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| 关 键 词： | 干扰素 p200 p204 心肌分化 干细胞 |
The Interferon-inducible p204 Protein Regulate Cardiac Differentiation:Mechanisms and Application Prospect |
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| Fang Song,Qiang Wu.The Interferon-inducible p204 Protein Regulate Cardiac Differentiation:Mechanisms and Application Prospect[J].Chinese Journal of Cell Biology,2011(1). |
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| Authors: | Fang Song Qiang Wu |
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| Institution: | Fang Song,Qiang Wu~* (Cardiovascular Institute of Guizhou,Department of Cardiology,Guizhou Province People's Hospital,Guiyang 550002,China) |
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| Abstract: | The interferon-inducible protein 200 family(p200) proteins,which have several common characteristic structures and are highly homologous to one another,include 6 kinds of murine and 4 kinds of human family members,are widely involved in regulating cell proliferation and differentiation,senescence and apoptosis, playing important roles in the autoimmune response,anti-virus,anti-cancer and other fields.The endogenous murine p204 of p200 family proteins has the highest expression in heart and skeletal muscle,s... |
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| Keywords: | interferon p200 p204 cardiac differentiation stem cell |
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